SALT LAKE CITY people who face particular risks of colon cancer will soon have a better chance to survive or even to avoid the disease.
Thanks to LDS Institute new studies by a group of scientists at the Intermontain Intermountain Healthcare Clinical Genetics hospital. Scientists use sophisticated computer modeling to determine, an accurate way and costs relatively less expensive, to identify patients who wear may be a Lynch syndrome, a congenital cancer syndrome that is running in people, a genetic mutation in a gene DNA undergoes an outsider.
Mismatch repair (MMR) gene helps to repair DNA damage, which occurs the patient usually. But also patients who have a genetic mutation in this gene an increased risk of more fundamental have in the development of colorectal cancer, womb, pancreas and cancer of the urinary tract. In some patients, the risk of a lifetime reaches 80%.
"Able to identify people, who carry the gene changes very important because it is a screening earlier and more often against colorectal cancer can perform." This could save her life. It can also store that does not endanger the lives of our brothers and sisters, who were previously because they can share an increased risk for cancer genes, "explains Marc S. Williams, MD, Director of the Institute of clinical genetics LDS hospital and a member of the team, the research, in: American Journal of managed care has released."
James Cudgeon, analyst of the Institute of clinical genetics is the leader of which research shows there are a number of tests available, which can be used in various combinations, the Lynch syndrome, currently there is clarity, to use methods, the effective and efficient are to diagnose. As do a number of genetic test for patients Koceh USD 4000 up to 6,000 USD per person, so each test will be very expensive and inefficient. Like quotation marks Eurek alert, Tuesday (17/8/2011).
Largest team sense to develop of a system to do a test screening in colorectal cancer by pressing charges being made, but still accurate results sets. The team gathers information from various sources, including Intermountain patient data.
So far, patients with colorectal cancer in the Intermontain amounted to 272 and has according to the system group was shown. There are 261 individuals are excluded because of the abnormal gene as a carrier.
"It means only the remaining 11 patients, we would recommend that to do a complete set of tests Ginetik." It is the wisest decision, given the expensive cost a full review of "Whale of Dr Williams."
The advantages of this test expand not only the lives of patients with colorectal cancer, but also to prevent the spread in their family who may have also a mutation of the MMR.
You can make patients more vigilant against cancer. Some women who are diagnosed with Lynch syndrome can have surgery, the uterus and ovaries to prevent uterine or ovarian cancer to remove.
"The team developed computer models that are tailored to examine a wide range of issues, which is decided by the Intermountain." You are generally interested in this kind of work on health systems do search. We think this application modeling can help, the health system is much better. This can help improve healing of patients and cost-efficiency, that's the hope which favoured by the Intermountain Healthcare Research, "Dr. Wiliam knot." (Type)
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